反应详情

To a suspension of 2-chloro-3,4-dihydro-6-(3,4-dimethoxyphenyl)-3-methyl-4-(2,4,6-trimethylphenylimino)pyrimidine (2.08 g) in ethanol (20 ml) was added 1,2,3,6-tetrahydropyridine (1.38 ml), and refluxed for 1.5 hours. The resulting precipitates were collected, dissolved in chloroform, washed with aqueous sodium bicarbonate solution, and dried over magnesium sulfate. After evaporated, the residue was triturated with diisopropyl ether to give 3,4-dihydro-6-(3,4-dimethoxyphenyl)-3-methyl-2-(1,2,3,6-tetrahydropyridin-1-yl)-4-(2,4,6-trimethylphenylimino)pyrimidine (1.95 g).

1. temperaturerefluxed for 1.5 hours
2. customThe resulting precipitates
3. customwere collected
4. dissolutiondissolved in chloroform
5. washwashed with aqueous sodium bicarbonate solution
6. dry with materialdried over magnesium sulfate
7. customAfter evaporated
8. customthe residue was triturated with diisopropyl ether