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HRID434741

反应详情

EQUATION

反应方程式

HRID 434741 的结构方程式

REACTANTS

反应物

1
结构：CC(=O)OC[C@H]1O[C@@H](Sc2ccc(NC(=O)CCCCCCC(=O)Nc3ccc(S[C@@H]4O[C@H](COC(C)=O)[C@@H](O[C@H]5O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]5OC(C)=O)[C@H](OC(C)=O)[C@H]4OC(C)=O)cc3)cc2)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1O[C@H]1O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O
HCID53876502

未命名化合物

PRODUCTS

生成物

1
结构：O=C(CCCCCCC(=O)Nc1ccc(S[C@@H]2O[C@H](CO)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)cc1)Nc1ccc(S[C@@H]2O[C@H](CO)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)cc1
HCID54443576

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：N
溶剂HCID222

Ammonia gas

H3N

结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

A 28.4 g portion of N,N'-bis[4-[2,3,6-tri-O-acetyl-4-O-(2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl)-β-D-glucopyranosylthio]phenyl]octanediamide was dissolved in a 0° C. solution of 500 ml of methanol saturated with ammonia. The solution was allowed to stand at 0° C., under an inert atmosphere, for 18 hours, then was warmed to ambient temperature and evaporated. The residue was triturated with 200 ml of absolute ethanol, filtered, washed in sequence with absolute ethanol, acetonitrile, then ether and dried in vacuo at 40° C., giving 12.1 g of the desired intermediate as an amorphous solid.

WORKUP

后处理

  1. customevaporated
  2. customThe residue was triturated with 200 ml of absolute ethanol
  3. filtrationfiltered
  4. washwashed in sequence with absolute ethanol, acetonitrile
  5. dry with materialether and dried in vacuo at 40° C.