反应详情

In the manner of Example VII, 7 g of N'-(4-cyano- 3-isopropyl-5-isothiazolyl)-N,N-dimethylchloroformamidine, 3.6 g of anhydrous potassium cyanide, and a catalytic amount of 2,3,11,12-dibenzo-1,4,7,10,13,16-hexaoxacycloocta- 2,11-diene in 200 ml of dry aceto-nitrile were allowed to react for several days. After solvents were removed under reduced pressure, the residue was recrystallized from methylcyclohexane to yield 4.3 g of N'-(4-cyano-3-isopropyl-5-isothiazolyl)-N,N-dimethylcyanoformamidine, mp 78°-79°. The ir and nmr spectra were consistent with the assigned structure.

1. customto react for several days
2. customAfter solvents were removed under reduced pressure
3. customthe residue was recrystallized from methylcyclohexane