HCID 131730870, compound → Methyl cis(+/-)-3-(4-amino-3-ethoxypiperidin-1-yl)benzoate

HRID 43786Notes

Reaction equation

HRID 43786 reaction equation
C(OC([NH:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:19]=[C:20]([CH:25]=[CH:26][CH:27]=2)[C:21]([O:23][CH3:24])=[O:22])[CH2:14][C@H:13]1[O:28][CH2:29][CH3:30])=O)C1C=CC=CC=1>[C].[Pd]>[NH2:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:19]=[C:20]([CH:25]=[CH:26][CH:27]=2)[C:21]([O:23][CH3:24])=[O:22])[CH2:14][C@H:13]1[O:28][CH2:29][CH3:30]

Participants

3

Reactant 1

HCID 131730870HCID 131730870, compound

Product 1

HCID 86648736Methyl cis(+/-)-3-(4-amino-3-ethoxypiperidin-1-yl)benzoateYield 22.7%

Reagents, catalysts & solvents 1

HCID 178418390HCID 178418390, compoundCatalyst

Procedure

The same operation as in Example (160c) was performed using methyl cis(±)-3-(4-{[(benzyloxy)carbonyl]amino}-3-ethoxypiperidin-1-yl)benzoate obtained in Example (48c) (155 mg, 0.38 mmol) and a 10% palladium-carbon catalyst (200 mg), to obtain 24 mg of the title compound as a pale yellow oily substance. The resulting compound was used for the next reaction without purification.

Sources & evidence

ORD record
ord-3eb637e1c12740ca9820a5cdbc8d2cd8
Source dataset
uspto-grants-2013_09
Patent number
US08536197B2

Reaction notes

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