反应详情

温度

70 °C

Methyl cis(±)-2-(acetylamino)-5-(4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-methoxypiperidin-1-yl)benzoate obtained in Example (185e) (120 mg) was dissolved in methanol (4 ml) and THF (4 ml). A 2 N aqueous lithium hydroxide solution (2 ml) was added, and the mixture was stirred at 70° C. for one hour. The organic solvent was evaporated under reduced pressure, followed by neutralization with 1 N hydrochloric acid and extraction with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate. Following concentration under reduced pressure, the residue was recrystallized from an ethyl acetate/methanol/hexane solvent to obtain 90 mg of the title compound as crystals.

1. customThe organic solvent was evaporated under reduced pressure
2. extractionfollowed by neutralization with 1 N hydrochloric acid and extraction with ethyl acetate
3. dry with materialThe organic layer was dried over anhydrous sodium sulfate
4. concentrationconcentration under reduced pressure
5. customthe residue was recrystallized from an ethyl acetate/methanol/hexane solvent