HCID 86648860, compound → Ammonium formate

HRID 43980Notes

Reaction equation

HRID 43980 reaction equation
C([N:8](C(OCC1C=CC=CC=1)=O)[C@H:9]1[CH2:14][CH2:13][N:12]([C:15]2[C:16]([F:25])=[C:17]([CH:22]=[CH:23][CH:24]=2)[C:18]([O:20][CH3:21])=[O:19])[CH2:11][C@H:10]1[O:26][CH3:27])C1C=CC=CC=1>[C].[Pd].CO>[CH:18]([O-:20])=[O:19].[NH4+:8].[NH2:8][C@H:9]1[CH2:14][CH2:13][N:12]([C:15]2[C:16]([F:25])=[C:17]([CH:22]=[CH:23][CH:24]=2)[C:18]([O:20][CH3:21])=[O:19])[CH2:11][C@H:10]1[O:26][CH3:27]

Participants

5

Reactant 1

HCID 86648860HCID 86648860, compound

Product 2

HCID 2723923Ammonium formateYield 2,033.3%HCID 86648859HCID 86648859, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

The same operation as in Example (90d) was performed using methyl cis(±)-3-(4-{benzyl[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-2-fluorobenzoate obtained in Example (263a) (31 mg, 0.06 mmol), a 10% palladium-carbon catalyst (20 mg), ammonium formate (39 mg, 0.61 mmol) and methanol (4 mL), to obtain the title compound. The resulting compound was used for the next reaction without purification.

Sources & evidence

ORD record
ord-3537a2e10a1048d4af5359289dc523a9
Source dataset
uspto-grants-2013_09
Patent number
US08536197B2

Reaction notes

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