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HRID440106

反应详情

EQUATION

反应方程式

HRID 440106 的结构方程式

REACTANTS

反应物

1
结构：CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C(=O)OCc1ccccc1
HCID15288085

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1
HCID454736

(3S,4aS,8aS)-N-tert-Butyldecahydroisoquinoline-3-carboxamide

C14H26N2O

收率 100%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[Pd]
催化剂HCID23938

Palladium

Pd

结构：CCO
溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

A solution of 0.689 g (1.85 mmol) of 2-(benzyloxycarbonyl)-N-tert.butyl-decahydro-(4aS,8aS)-isoquinoline-3(S)-carboxamide in 20 ml of ethanol was hydrogenated in the presence of 0.01 g of 10% palladium-on-carbon at room temperature and under atmospheric pressure for 18 hours. The catalyst was removed by filtration and the solvent was removed by evaporation to give 1.85 mmol of N-tert.butyldecahydro-(4aS,8aS)-isoquinoline-3(S)-carboxamide as a clear oil: MS: m/e 239 [M+H]+, which was used in the next step without further purification.

WORKUP

后处理

  1. customThe catalyst was removed by filtration
  2. customthe solvent was removed by evaporation