反应详情

2.0 g (6.7 mmol) of 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-3,4-dihydro-5H-2,3-benzodiazepine were refluxed with 40 ml of acetic anhydride for 3 hours, then it was evaporated to dryness under reduced pressure. The crystalline residue was transferred with 25 ml of water to a filter and washed with 5×3 ml of water. After drying 2.79 g of the raw triacetyl derivative were obtained. After washing with 20 ml of isopropanol and drying at 100° C. 2.39 g (84.6%) of the pure aimed product were obtained, m.p. 224°-227° C.

1. customit was evaporated to dryness under reduced pressure
2. filtrationa filter
3. washwashed with 5×3 ml of water
4. dry with materialAfter drying 2.79 g of the raw triacetyl derivative
5. customwere obtained
6. washAfter washing with 20 ml of isopropanol
7. customdrying at 100° C