反应详情

A solution of 1.0 gm (3.73 mMol) 5-fluoro-3-(4-piperidinyl)-1H-indole and 2.4 gm (7.5 mMol) 3,4,6-trichlorophenoxy 2-(4-pyridinyl)acetate in 40 mL dimethylformamide were stirred at ambient temperature for 18 hours under a nitrogen atmosphere. The reaction mixture was concentrated under reduced pressure and the residue partitioned between ethyl acetate and aqueous sodium bicarbonate solution. The phases were separated and the organic extract dried over sodium sulfate then concentrated under reduced pressure. The resultant oil was subjected to silica gel chromatography, eluting with a gradient of ethyl acetate containing 0-5% methanol. Fractions shown to contain the desired amide were combined and concentrated under reduced pressure to give 5-fluoro-3-[1-(2-(4-pyridinyl)acetyl)-4-piperidinyl]-1H-indole as a colorless solid.

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. customthe residue partitioned between ethyl acetate and aqueous sodium bicarbonate solution
3. customThe phases were separated
4. extractionthe organic extract
5. dry with materialdried over sodium sulfate
6. concentrationthen concentrated under reduced pressure
7. washeluting with a gradient of ethyl acetate containing 0-5% methanol
8. concentrationconcentrated under reduced pressure