HRID443268

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID9795357

未命名化合物

结构：CCOC(=O)C1(Cc2cccc(CNS(C)(=O)=O)c2)CCNCC1.Cl

HCID21193259

未命名化合物

HCID21193348

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)C1(Cc2cccc(CNS(C)(=O)=O)c2)CCN(Cc2cnc(C)n2Cc2ccc(C#N)cc2)CC1

HCID21193334

未命名化合物

PROCEDURE

实验过程

The title compound was prepared using the protocol described in Example 61, Step C substituting methyl 4-(3-methylbenzyl)piperidine-4-carboxylate hydrochloride salt with ethyl 4-[3-(methanesulfonylamino-methyl)benzyl]piperidine-4-carboxylate hydrochloride salt, and 1-(4-cyanobenzyl)-5-chloromethylimidazole hydrochloride salt with 1-(4-cyanobenzyl)-5-chloromethyl-2-methylimidazole hydrochloride salt (Example 53, Step B). After column chromatography on silica gel, the free base obtained was triturated with anhydrous diethyl ether. The white solid precipitated was filtered, and residual solvent was removed under vacuum overnight to provide the title compound.

WORKUP

后处理

customThe title compound was prepared
customAfter column chromatography on silica gel, the free base obtained
customwas triturated with anhydrous diethyl ether
customThe white solid precipitated
filtrationwas filtered
customresidual solvent was removed under vacuum overnight

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b8e373ba3b7847d7b0e54ad9cff89780
来源数据集: uspto-grants-1999_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05891889
来源说明: uspto-grants-1999_04

反应 SMILES

Cl.[CH3:2][S:3]([NH:6][CH2:7][C:8]1[CH:9]=[C:10]([CH:23]=[CH:24][CH:25]=1)[CH2:11][C:12]1([C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1)(=[O:5])=[O:4].Cl.C(C1C=CC(CN2C(CCl)=CN=C2)=CC=1)#N.Cl.[C:44]([C:46]1[CH:60]=[CH:59][C:49]([CH2:50][N:51]2[C:55]([CH2:56]Cl)=[CH:54][N:53]=[C:52]2[CH3:58])=[CH:48][CH:47]=1)#[N:45]>>[C:44]([C:46]1[CH:47]=[CH:48][C:49]([CH2:50][N:51]2[C:55]([CH2:56][N:15]3[CH2:16][CH2:17][C:12]([CH2:11][C:10]4[CH:23]=[CH:24][CH:25]=[C:8]([CH2:7][NH:6][S:3]([CH3:2])(=[O:4])=[O:5])[CH:9]=4)([C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH2:13][CH2:14]3)=[CH:54][N:53]=[C:52]2[CH3:58])=[CH:59][CH:60]=1)#[N:45]