反应详情

Add 5.75 g of 4-cyanophenol 10 g of 1 brom-6-methyl octane synthesized of available active amyl alcohol, 6.67 g of anhydrous potassium carbonate, 30 ml of N,N-dimethyl formamide into 100 ml four-mouth flask under nitrogen atmosphere, allow to react for 8 hours at 110° C. After the reaction, filter the insoluble matter, then extract ether. The organic layer is then washed with 5% NaOH, water and saturated salt water, then dried and evaporated to remove the ether. Then when the obtained oily matter is refined, 11.4 g of optical (s)-4-(6-methyloctyloxy)benzonitrile is obtained.

1. customto react for 8 hours at 110° C
2. customAfter the reaction
3. filtrationfilter the insoluble matter
4. washThe organic layer is then washed with 5% NaOH, water and saturated salt water
5. customdried
6. customevaporated
7. customto remove the ether