5-Bromo-3-isopropoxy-2-methylpyridine → 5-Bromo-3-isopropoxy-2-methyl-pyridine 1-oxide

HRID 445737Notes

Reaction equation

HRID 445737 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([O:9][CH:10]([CH3:12])[CH3:11])[C:5]([CH3:8])=[N:6][CH:7]=1.C([O:17]C(=O)N(C1C(C)=NC=C(Br)C=1)CC)(C)(C)C>>[Br:1][C:2]1[CH:3]=[C:4]([O:9][CH:10]([CH3:12])[CH3:11])[C:5]([CH3:8])=[N+:6]([O-:17])[CH:7]=1

Participants

3

Reactant 2

HCID 596129725-Bromo-3-isopropoxy-2-methylpyridineHCID 59613068(5-Bromo-2-methyl-pyridin-3-yl)-ethyl-carbamic acid tert-butyl ester

Product 1

HCID 672662245-Bromo-3-isopropoxy-2-methyl-pyridine 1-oxide

Procedure

The title compound was synthesized in a similar manner as described for Stage 155.1.4 using 5-bromo-3-isopropoxy-2-methyl-pyridine (Stage 84.1.2, 2.108 mmol) as replacement for (5-bromo-2-methyl-pyridin-3-yl)-ethyl-carbamic acid tert-butyl ester to give the title compound as a slowly crystallizing orange solid. (HPLC: tR 2.75 min (Method A); M+H=246, 248 MS-ES).

Workup

  1. customThe title compound was synthesized in a similar manner

Sources & evidence

ORD record
ord-925ed66be88e4cc7afb58a998ad8759b
Source dataset
uspto-grants-2013_07
Patent number
US08476294B2

Reaction notes

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