反应详情

A mixture of tert-butyl 4-{[(benzyloxy)carbonyl]amino}piperidine-1-carboxylate obtained in Example 1a (13.1 g, 39.2 mmol), a 5 N aqueous hydrochloric acid solution (40 ml, 200 mmol) and methanol (40 ml) was stirred at mom temperature for 23 hours. A 5 N aqueous sodium hydroxide solution (40 ml) was added to the reaction mixture under ice-cooling. Water and the solvent were distilled off from the reaction mixture while the mixture was azeotropically distilled with ethanol. Ethanol was added to the residue, the insoluble matter was removed by filtration, and the filtrate was concentrated to give the title compound (9.10 g, yield 99.1%).

1. temperaturecooling
2. distillationWater and the solvent were distilled off from the reaction mixture while the mixture
3. distillationwas azeotropically distilled with ethanol
4. additionEthanol was added to the residue
5. customthe insoluble matter was removed by filtration
6. concentrationthe filtrate was concentrated