反应详情

Methanol (3 ml) and 10% Pd/C (30 mg) were added to 1-benzyl 3-(4-methoxyphenyl)methyl (3R*,4S*)-3-[2-(tert-butoxy)-2-oxoethyl]-4-methylpyrrolidine-1,3-dicarboxylate which is obtained in Example 4d and which is without silica gel column chromatography purification (104 mg, 0.21 mmol), followed by stirring at mom temperature overnight under a hydrogen atmosphere. Water was added to the reaction liquid, which was stirred and filtered. The filtrate was concentrated to give the title compound (48.7 mg, yield: 95.3%).

1. customis obtained in Example 4d and which
2. customis without silica gel column chromatography purification (104 mg, 0.21 mmol)
3. additionWater was added to the reaction liquid, which
4. stirringwas stirred
5. filtrationfiltered
6. concentrationThe filtrate was concentrated