反应详情

(9-(3-(2-Hydroxyethyl)phenethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-isopropylthiazol-4-yl)methanone [Example 34, step a] (2.4 g) was dissolved in acetonitrile (2 mL) and tert-butyl acrylate (1.7 mL) added, followed by benzyltrimethylammonium hydroxide (40% in water, 0.72 mL). The mixture was stirred at ambient temperature for 3 hours. The volatiles were removed under reduced pressure and the residue purified by flash silica chromatography eluting with 3% methanol in dichloromethane containing 1% ‘880’ aqueous ammonia to afford the subtitled compound Yield 2.7 g.

1. customThe volatiles were removed under reduced pressure
2. customthe residue purified by flash silica chromatography
3. washeluting with 3% methanol in dichloromethane containing 1% ‘880’ aqueous ammonia