反应详情

A mixture of 3-(4-(benzyloxy)phenyl)-4-(pyridin-4-yl)furan-2(5H)-one (1.0 g, 0.002 mol) in 33% HBr/AcOH (50 mL) was refluxed for 3 h. The reaction mixture was quenched with a saturated NaHCO3 solution and extracted with EtOAc (2×50 mL). The combined organic layers were washed with water, dried over Na2SO4, filtered, and concentrated in vacuo to afford 3-(4-hydroxyphenyl)-4-(pyridin-4-yl)furan-2(5H)-one (0.7 g, 95%).

1. temperaturewas refluxed for 3 h
2. customThe reaction mixture was quenched with a saturated NaHCO3 solution
3. extractionextracted with EtOAc (2×50 mL)
4. washThe combined organic layers were washed with water
5. dry with materialdried over Na2SO4
6. filtrationfiltered
7. concentrationconcentrated in vacuo