反应详情

(R)-8-cyclopentyl-2-(2-(3,6-dihydro-2H-pyran-4-yl)-1H-imidazol-1-yl)-7-ethyl-5-methyl-7,8-dihydropteridin-6(5H)-one (Example 84, 34 mg) in 5 mL of MeOH, Pd/C (20 mg) was added. This reaction mixture was placed under a hydrogen balloon until all the starting material was consumed. The resulting mixture was filtered through a plug of Celite, and the plug was washed several times with EtOAc. The mixture was concentrated under reduced pressure and further purified by preparative HPLC. LCMS: 411.2 m/z (M+H)+; ret. Time: 6.45 min (Analytical Method C).

1. customwas consumed
2. filtrationThe resulting mixture was filtered through a plug of Celite
3. washthe plug was washed several times with EtOAc
4. concentrationThe mixture was concentrated under reduced pressure
5. customfurther purified by preparative HPLC