反应详情

To a solution of EtNH2 in alcohol (30% by weight, 10 mL) was added (3R)-tert-butyl 3-((3-chlorophenyl)(2-ethoxy-2-oxoethoxy)methyl)piperidine-1-carboxylate (100 mg, 0.243 mmol). The mixture was stirred at rt overnight. The mixture was concentrated under vacuum to give crude product, which was purified by preparative tlc (elution solvent: 5:1 petroleum ether/EtOAc) to give (3R)-tert-butyl 3-((3-chlorophenyl)(2-(ethylamino)-2-oxoethoxy)methyl)piperidine-1-carboxylate (57.9 mg. 58%) as a colorless oil. MS (E/Z): 411 (M+H+).

1. concentrationThe mixture was concentrated under vacuum
2. customto give crude product, which
3. customwas purified by preparative tlc (elution solvent: 5:1 petroleum ether/EtOAc)