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HRID451772

反应详情

EQUATION

反应方程式

HRID 451772 的结构方程式

REACTANTS

反应物

1
结构：CCC([C@H](CC1CCCCC1)NC(=O)OC(C)(C)C)N(C)C(=O)OCC[Si](C)(C)C
HCID68713330

未命名化合物

PRODUCTS

生成物

1
结构：CCC([C@@H](N)CC1CCCCC1)N(C)C(=O)OCC[Si](C)(C)C
HCID68713179

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CCO
溶剂HCID702

Ethanol

C2H6O

结构：CCOCC
溶剂HCID3283

Diethyl Ether

C4H10O

PROCEDURE

实验过程

The (2S)-tert-butyl 1-cyclohexyl-3-(N-methyl-N-(2-(trimethylsilyl)ethoxycarbonyl)amino)pentan-2-ylcarbamate (137 mg, 0.14 mmol) was dissolved in Et2O (5 mL), anhydrous TSA (24 mg, 0.14 mmol) dissolved in EtOH was added. The solvent was removed in vacuo using a hot bath at 60° C. for 30 min to give (S)-2-(trimethylsilyl)ethyl 2-amino-1-cyclohexylpentan-3-yl(methyl)carbamate. MS ESI +ve m/z 343 (M+H).

WORKUP

后处理

  1. additionwas added
  2. customThe solvent was removed in vacuo
  3. customat 60° C.
  4. customfor 30 min