反应详情

The (S)-tert-butyl 2,2-dimethyl-4-(((R,Z)-2,3,4,7-tetrahydrooxepin-3-yl)methyl)oxazolidine-3-carboxylate was dissolved in EtOH, followed by the addition of Raney Ni. The mixture was hydrogenated at rt for 3 h. The catalyst was filtered off and the filtrate was concentrated under reduced pressure to afford (S)-tert-butyl 2,2-dimethyl-4-((R)-oxepan-3-ylmethyl)oxazolidine-3-carboxylate (408 mg, 72%).

1. filtrationThe catalyst was filtered off
2. concentrationthe filtrate was concentrated under reduced pressure