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HRID451910

反应详情

EQUATION

反应方程式

HRID 451910 的结构方程式

REACTANTS

反应物

2
结构：CCO.CN
HCID22028356

未命名化合物

结构：COC(=O)CCCO[C@@H](c1cccc(Cl)c1)[C@@H]1CCCN(C(=O)N[C@@H](CC2CCCCC2)CN(C)C(=O)OC(C)(C)C)C1
HCID59201638

未命名化合物

PRODUCTS

生成物

1
结构：CNC(=O)CCCO[C@@H](c1cccc(Cl)c1)[C@@H]1CCCN(C(=O)N[C@@H](CC2CCCCC2)CN(C)C(=O)OC(C)(C)C)C1
HCID59201385

未命名化合物

收率 71%

PROCEDURE

实验过程

methyl 4-((R)—((R)-1-((S)-1-(tert-butoxycarbonyl(methyl)amino)-3-cyclohexylpropan-2-ylcarbamoyl)piperidin-3-yl)(3-chlorophenyl)methoxy)butanoate (70 mg, 0.11 mmol) was dissolved in the CH3NH2/C2H5OH (20 mL), which was stirred at rt overnight. After the reaction was completed, the solvent was removed in vacuo. The product was purified via preparative TLC to afford tert-butyl (S)-2-((R)-3-((R)-(3-chlorophenyl)(4-(methylamino)-4-oxobutoxy)methyl)piperidine-1-carboxamido)-3-cyclohexylpropyl(methyl)carbamate (50 mg, 71% yield), which was used immediately in the next step.

WORKUP

后处理

  1. customthe solvent was removed in vacuo
  2. customThe product was purified via preparative TLC