反应详情

Following the procedure as described in Example 2, making variations only as required to use 3,5-difluorobenzoyl chloride in place of benzoyl chloride to react with 2-amino-4-methylthiazole-5-carboxylic acid benzylamide, the title compound was obtained as a white solid in 48% yield; m.p. 84-86° C.; 1H NMR (CDCl3, 300 MHz) δ 7.44-7.24 (m, 7H), 7.01 (tt, J=2.2, 8.4 Hz, 1H), 6.05 (s, 1H), 4.58 (d, J=5.6 Hz, 2H), 2.41 (s, 3H); MS (ES+) m/z 388.1 (M+1).