反应详情

温度

100 °C

A suspension of 4-chloro-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline (130 mg, 0.4 mmol), (prepared as described for the starting material in Example 10), 7-hydroxy-2-methylchromone (88 mg, 0.5 mmol), (Bull Soc. Chim. Fr. 1995, 132, 233), and potassium carbonate (83 mg, 0.6 mmol) was heated at 100° C. for 1.5 hours. After cooling, the mixture was partitioned between water and ethyl acetate. The organic layer was washed with water, brine, dried (MgSO4), and the volatiles were removed by evaporation. The residue was triturated with ether, collected by filtration, washed with ether and dried under vacuum to give 6-methoxy-4-(2-methyl-4-oxo-4H-chromen-7-yloxy)-7-(1-methylpiperidin-4-ylmethoxy)quinazoline (170 mg, 92%).

1. custom(prepared
2. temperatureAfter cooling
3. customthe mixture was partitioned between water and ethyl acetate
4. washThe organic layer was washed with water, brine
5. dry with materialdried (MgSO4)
6. customthe volatiles were removed by evaporation
7. customThe residue was triturated with ether
8. filtrationcollected by filtration
9. washwashed with ether
10. customdried under vacuum