反应详情

温度

90 °C

A suspension of 4-chloro-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline (50 mg, 0.155 mmol), (prepared as described for the starting material in Example 10), and 5-hydroxy-2-trifluoromethylindole (34 mg, 0.17 mmol) in DMF (1.5 ml) containing potassium carbonate (43 mg, 0.31 mmol) was heated at 90° C. for 2 hours. After cooling, the mixture was partitioned between ethyl acetate and water. The organic layer was separated, washed with brine, dried (MgSO4) and the volatiles were removed by evaporation. The residue was purified by column chromatography eluting with methanol/ethyl acetate/methylene chloride (10/50/40) followed by 2.5M ammonia in methanol/ethyl acetate/methylene chloride (10/50/40) to give 6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)-4-(2-trifluoromethylindol-5-yloxy)quinazoline (35 mg, 48%).

1. custom(prepared
2. temperatureAfter cooling
3. customthe mixture was partitioned between ethyl acetate and water
4. customThe organic layer was separated
5. washwashed with brine
6. dry with materialdried (MgSO4)
7. customthe volatiles were removed by evaporation
8. customThe residue was purified by column chromatography
9. washeluting with methanol/ethyl acetate/methylene chloride (10/50/40)