反应详情

温度

-3 °C

A suspension of methyltriphenylphosphonium bromide (1.31 g, 3.67 mmol, 3.67 mmol, 2.0 equiv) in THF (15 mL) was cooled to ˜−3° C. and 2.5M n-BuLi in hexanes (1.4 mL, 3.5 mmol, 1.9 equiv) was added dropwise at <2° C. The yellow light suspension was allowed to warm to room temperature and stirred 1 hr. The mixture was cooled to ˜3° C. and a solution of 12 (0.67 g, 1.84 mmol, 1.0 equiv) in THF (5 mL) was added at <5° C. The mixture was allowed to warm to room temperature and stirred 3 hr. TLC (25% EtOAc/heptanes) showed the reaction was complete. The mixture was quenched by addition saturated NH4Cl solution (5 mL). The mixture was partitioned between EtOAc (75 mL) and H2O (5 mL). The organic phase was washed with brine (25 mL), dried over Na2SO4, filtered and the solution concentrated under reduced pressure to give a yellow-orange oil (crude weight=1.41 g). The crude product was absorbed onto silica gel using DCM and dry-loaded on a column of silica gel (15 g) packed in hexanes. The column was eluted with hexanes (100 mL), 5% EtOAc/hexanes (200 mL) and 10% EtOAc/hexanes (200 mL). Product fractions were concentrated under reduced pressure and the residue dried under high vacuum for 1 hr to give 0.64 g of 13 as a colorless, viscous oil.

1. temperatureto warm to room temperature
2. temperatureThe mixture was cooled to ˜3° C.
3. temperatureto warm to room temperature
4. stirringstirred 3 hr
5. customThe mixture was quenched by addition saturated NH4Cl solution (5 mL)
6. customThe mixture was partitioned between EtOAc (75 mL) and H2O (5 mL)
7. washThe organic phase was washed with brine (25 mL)
8. dry with materialdried over Na2SO4
9. filtrationfiltered
10. concentrationthe solution concentrated under reduced pressure
11. customto give a yellow-orange oil (crude weight=1.41 g)
12. customThe crude product was absorbed onto silica gel
13. washThe column was eluted with hexanes (100 mL), 5% EtOAc/hexanes (200 mL) and 10% EtOAc/hexanes (200 mL)
14. concentrationProduct fractions were concentrated under reduced pressure
15. customthe residue dried under high vacuum for 1 hr