HRID454622

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CN1CCC(Oc2ccc(OCc3ccccc3)c(C(=O)Nc3cc(-c4ccccc4)ccc3C(=O)OC(C)(C)C)c2)CC1

HCID66991124

未命名化合物

PRODUCTS

生成物

结构：CN1CCC(Oc2ccc(O)c(C(=O)Nc3cc(-c4ccccc4)ccc3C(=O)OC(C)(C)C)c2)CC1

HCID58508711

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID178418390

未命名化合物

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

To a methanol (5.0 mL) solution of the obtained tert-butyl 2-(2-(benzyloxy)-5-((1-methylpiperidin-4-yl)oxy)benzamido)-4-phenylbenzoate, 10% palladium-carbon (0.11 g) was added, followed by stirring under a hydrogen atmosphere at room temperature for 2 hours and 40 minutes. The insoluble substance was removed by filtration, and the obtained residue was purified by silica gel column chromatography [eluent: 100-90% chloroform/methanol] to obtain 0.13 g of tert-butyl 2-(2-hydroxy-5-((1-methylpiperidin-4-yl)oxy)benzamido)-4-phenylbenzoate as a light yellow solid.

WORKUP

后处理

customThe insoluble substance was removed by filtration
customthe obtained residue was purified by silica gel column chromatography [eluent: 100-90% chloroform/methanol]

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b3d056cc19564e08a2f14d2f6bc84788
来源数据集: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08492582B2
来源说明: uspto-grants-2013_07

反应 SMILES

C([O:8][C:9]1[CH:36]=[CH:35][C:34]([O:37][CH:38]2[CH2:43][CH2:42][N:41]([CH3:44])[CH2:40][CH2:39]2)=[CH:33][C:10]=1[C:11]([NH:13][C:14]1[CH:26]=[C:25]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH:24]=[CH:23][C:15]=1[C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])=[O:12])C1C=CC=CC=1>[C].[Pd].CO>[OH:8][C:9]1[CH:36]=[CH:35][C:34]([O:37][CH:38]2[CH2:39][CH2:40][N:41]([CH3:44])[CH2:42][CH2:43]2)=[CH:33][C:10]=1[C:11]([NH:13][C:14]1[CH:26]=[C:25]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH:24]=[CH:23][C:15]=1[C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])=[O:12]