反应详情

The title compound was prepared according to Method A and the experimentals described for compound 1 from 6-chloro-3-(chloromethyl)-2-phenylimidazo[1,2-a]pyridine hydrochloride and methyl 1H-1,2,4-triazole-3-carboxylate. The two isomers were separated by silica gel chromatography (eluted with 20% acetone/hexane to flush out the less polar isomer (44) and then flashed with 50% acetone to get the second compound off the column (45). Compound 44: m/e+ 368 for C18H15ClN5O2 [M+H]−; 1H-NMR (400 MHz, CDCl3) δ 8.35 (d, J=1.1 Hz, 1H), 7.98 (s, 1H), 7.76 (dd, J=1.4, 8.0 Hz, 2H), 7.61 (d, J=9.5 Hz, 1H), 7.42 (m, 3H), 7.24 (m, 1H), 6.17 (s, 2H), 3.97 (s, 3H) ppm; Compound 45: m/e+ 368 for C18H15ClN5O2 [M+H]+; 1H-NMR (400 MHz, CDCl3) δ 8.18 (d, J=1.1 Hz, 1H), 7.99 (s, 1H), 7.63 (m, 3H), 7.44 (m, 3H), 7.25 (m, 1H), 5.82 (s, 2H), 3.97 (s, 3H) ppm.

1. customThe title compound was prepared
2. customThe two isomers were separated by silica gel chromatography (
3. washeluted with 20% acetone/hexane
4. customto flush out the less polar isomer (44)