反应详情

A solution of n-butyllithium (2.7N in heptanes; 165 mL, 445 mmol) in THF (300 mL) was cooled to −78° C. and treated with 2,2,6,6-tetramethylpiperidine (77 mL, 456 mmol). The reaction mixture was allowed to stir for 30 minutes. A solution of 5-chloro-2-fluoropyridine (50.0 g, 380 mmol) in THF (200 mL) was added drop wise over 30 minutes. After stirring for an additional 30 minutes, the reaction mixture was quenched by bubbling CO2 through the reaction mixture for 10 minutes. The reaction mixture was allowed to warm to RT, and CO2 was bubbled through for an additional 30 minutes. The reaction mixture was then concentrated under reduced pressure and dissolved in DMF (400 mL). 4-Bromo-3-fluorophenol (72.6 g, 380 mmol) was added, followed by potassium carbonate (68.3 g, 494 mmol). The reaction mixture was heated to 120° C. overnight. The reaction mixture was diluted with EtOAc and washed with 4N HCl. The organic layer was separated, washed with water and dried over MgSO4. The solvent was removed under reduced pressure. The crude residue was dissolved in Eaton's Reagent (700 mL, 54.0 g, 380 mmol) and the reaction mixture was heated to 120° C. overnight. The reaction mixture was poured onto a mixture of ice and MeOH. The resulting solid was filtered off and washed with water. The solid was suspended in a mixture of MeOH (100 mL) and cyclopropyl methyl ether (200 mL) and filtered off. The grey solid was washed with hexanes and dried yielding 7-bromo-3-chloro-8-fluoro-5H-chromeno[2,3-b]pyridin-5-one (53.76 g, 164 mmol, 43.0% yield) as a ˜4:1 mixture of isomers.

1. stirringAfter stirring for an additional 30 minutes
2. customthe reaction mixture was quenched
3. customby bubbling CO2 through the reaction mixture for 10 minutes
4. customCO2 was bubbled through for an additional 30 minutes
5. concentrationThe reaction mixture was then concentrated under reduced pressure
6. dissolutiondissolved in DMF (400 mL)
7. temperatureThe reaction mixture was heated to 120° C. overnight
8. washwashed with 4N HCl
9. customThe organic layer was separated
10. washwashed with water
11. dry with materialdried over MgSO4
12. customThe solvent was removed under reduced pressure
13. temperaturethe reaction mixture was heated to 120° C. overnight
14. filtrationThe resulting solid was filtered off
15. washwashed with water
16. additionThe solid was suspended in a mixture of MeOH (100 mL) and cyclopropyl methyl ether (200 mL)
17. filtrationfiltered off
18. washThe grey solid was washed with hexanes
19. customdried