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HRID458444

反应详情

EQUATION

反应方程式

HRID 458444 的结构方程式

REACTANTS

反应物

2
结构：CC1(C)OC(=O)CC(=O)O1
HCID16249

2,2-Dimethyl-1,3-dioxane-4,6-dione

C6H8O4

结构：CC(C)(C)OC(=O)N1CSC[C@H]1C(=O)O
HCID688405

(4R)-3-(tert-Butoxycarbonyl)-1,3-thiazolidine-4-carboxylic acid

C9H15NO4S

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N1CSC[C@H]1C(=O)C1C(=O)OC(C)(C)OC1=O
HCID90819551

未命名化合物

收率 89%

PROCEDURE

实验过程

A was prepared from (4R)-3-(tert-butoxycarbonyl)-1,3-thiazolidine-4-carboxylic acid (5.30 g, 22.7 mmol) and Meldrum's acid according to the previously described procedure used for Example 1C, giving the title compound as yellow solid (7.31 g, 89%). LCMS m/z 358 (M−H). 1H NMR (300 MHz, CDCl3, mixture of rotamers) δ 5.88 (m, 1H), 4.80–4.51 (m, 3H), 369 (m, 1H), 3.05 (m, 1H), 2.0–1.8 (m, 3H), 1.8–1.7 (m, 6H), 1.44 (s, 5H), 1.38 (s, 4H) ppm.