反应详情

Reaction of intermediate 12, ethyl 6-benzyloxy-1-methyl-2,5-dioxo-1,2,3,5-tetrahydroimidazo[1,2-a]pyrimidine-7-carboxylate, (0.500 g, 1.46 mmol) with trifluoroacetic acid (20 ml) as described in the preparation of intermediate 5 gave 0.308 g (83% yield) of the title ester as white crystals; mp 229–230° C. (ethyl acetate). 1HNMR 400 MHz (CDCl3) δ (ppm): 1.49 (3H, t, J=7.1 Hz, CH3), 3.31 (3H, s, NCH3), 4.51 (2H, q, J=7.2 Hz, OCH2), 4.55 (2H, s, CH2), 10.84 (2H, s, OH). Anal. Calcd for C10H11N3O5: C, 47.43; H, 4.37; N, 16.59. Found: C, 47.22; H, 4.13; N, 16.48.