反应详情

4-(2,2,3,3-tetrafluoro-propoxy)-benzyloxy-phenol (0.09 mmol, 28 mg) (Step A) was dissolved in MeOH (2 mL) and Pd(C) (40% weight, 10 mg) was added. The mixture was stirred for 90 minutes under H2 atmosphere (1 atm), and filtered through a celite pad (EtOH). The filtrate was concentrated to give the title compound. 1H-NMR (CDCl3, 200.15 MHz): δ 6.85–6.75 (m, 4H), 6.05 (dt, J=53.2, 4.8), 4.28 (dt, 2H, J=12.1, 1.6).

1. filtrationfiltered through a celite pad (EtOH)
2. concentrationThe filtrate was concentrated