反应详情

The title compound was prepared from 3-[3-(3-bromo-propoxy)-phenyl]-2-methoxy-propionic acid methyl ester (Example 323, Step 1) and 2-chlorophenol via the same procedure used for the preparation of (2S)-2-methoxy-3-[4-(3-phenoxy-propoxy)-phenyl]-propionic acid (Example 285, Step 1). The enatiomers were separated by chiral HPLC. 1H-NMR (CDCl3, 200.15 MHz): 7.35 (dd, 1H, J=8.1, 1.9), 7.24–7.16 (m, 2H), 6.97–6.80 (m, 5H), 4.22 (t, 2H, J=5.9), 4.20 (t, 2H, J=5.9), 4.02 (dd, 1H, J=7.3, 4.0), 3.39 (s, 3H), 3.13 (dd, 1H, J=14.2, 3.8), 2.97 (dd, 1H, J=14.0, 7.8), 2.30 (qn, 2H, J=6.2).

1. customThe enatiomers were separated by chiral HPLC