alpha-Methyl-p-phenethylbenzylamine hydrochloride → 2-[1-(6-tert.-butyl-1,1-dimethyl-4-indanyl)-ethylimino]hexahydro-1H-azepine hydrochloride
Reaction equation
[NH2:1][CH:2]([C:4]1[CH:12]=[C:11]([C:13]([CH3:16])([CH3:15])[CH3:14])[CH:10]=[C:9]2[C:5]=1[CH2:6][CH2:7][C:8]2([CH3:18])[CH3:17])[CH3:3].[ClH:19].C[CH:21]([NH2:36])[C:22]1C=[CH:26][C:25](CCC2C=CC=CC=2)=[CH:24][CH:23]=1>>[ClH:19].[C:13]([C:11]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][C:8]2([CH3:17])[CH3:18])=[C:4]([CH:2]([N:1]=[C:21]2[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][NH:36]2)[CH3:3])[CH:12]=1)([CH3:16])([CH3:15])[CH3:14]Participants
3
Procedure
Following essentially the same procedure described in Example 7 above and substituting 4-(α-aminoethyl)-1,1-dimethyl-6-tert.-butylindane for the α-methyl-p-phenethylbenzylamine hydrochloride above, results in the formation of 2-[1-(6-tert.-butyl-1,1-dimethyl-4-indanyl)-ethylimino]hexahydro-1H-azepine hydrochloride, having a M.P. of 257°-8° C. (dec.).
Sources & evidence
- ORD record
- ord-964af05d27e141678250fdfd9b51e051
- Source dataset
- uspto-grants-1977_12
- Patent number
- US04061746
Reaction notes
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