反应详情

To a 5 L 3-neck flask was added 284 g (2.06 moles) milled potassium carbonate and 1.0 L dimethylformamide. While stirring the resulting mixture at room temperature, 250 g (1.06 moles) 4-benzyloxyaniline hydrochloride was added portionwise over 15 minutes. After this was completed, 231 g (1.0 mole) 2-bromo-5-methoxybenzoic acid was added over 15 minutes and the mixture was stirred for another 15 minutes. The suspension was cooled to 10°-15° C. and 13.8 g cupric acetate monohydrate (0.06 moles) was added portionwise over 20 minutes. Gas evolved slowly and after stirring 15 minutes at room temperature the reaction was warmed on a steam bath over 40 minutes to 70° C. whereupon a vigorous evolution of carbon dioxide was observed. Stirring and heating was continued for 90 minutes at 80°-85°C., heat was removed and the mixture was allowed to cool to room temperature. The brownish red suspension was transferred to a 12 L flask containing 1 L ice-cold water. Acetic acid (650 ml) was added dropwise and the dark green precipitate was stirred vigorously until homogeneous. After filtering and washing well with water, the crude product was dried overnight at 55°-60° C. in a vacuum oven. The crude product (approximately 350 g) was diluted with 5.8 L toluene, heated to reflux temperature and filtered. The dark green filtrate was allowed to cool to room temperature for 2-3 hours, and the solid product was collected by filtration and rinsed with cold (5°-10° C.) toluene. The bright yellow crystalline product was obtained in 80% yield. A sample of the compound had the m.p. 167°-168° C. when recrystallized from a benzene-cyclohexane mixture.

1. additionTo a 5 L 3-neck flask was added 284 g (2.06 moles)
2. stirringthe mixture was stirred for another 15 minutes
3. temperatureThe suspension was cooled to 10°-15° C.
4. stirringafter stirring 15 minutes at room temperature the reaction
5. stirringStirring
6. temperatureheating
7. temperatureheat
8. customwas removed
9. temperatureto cool to room temperature
10. customThe brownish red suspension was transferred to a 12 L flask
11. additioncontaining 1 L ice-cold water
12. additionAcetic acid (650 ml) was added dropwise
13. stirringthe dark green precipitate was stirred vigorously until homogeneous
14. filtrationAfter filtering
15. washwashing well with water
16. dry with materialthe crude product was dried overnight at 55°-60° C. in a vacuum oven
17. additionThe crude product (approximately 350 g) was diluted with 5.8 L toluene
18. temperatureheated
19. temperatureto reflux temperature
20. filtrationfiltered
21. temperatureto cool to room temperature for 2-3 hours
22. filtrationthe solid product was collected by filtration
23. washrinsed with cold (5°-10° C.) toluene
24. customThe bright yellow crystalline product was obtained in 80% yield
25. customrecrystallized from a benzene-cyclohexane mixture