反应详情

tert-Butyl 4-[2-methoxy-5-(trifluoromethyl)phenyl]-3,6-dihydropyridine-1(2H)-carboxylate (Preparation 319, 512 mg, 1.43 mmol) was hydrogenated for 16 hours over palladium (10 wt. % on activated carbon, 10 mg, 0.009 mmol) at a pressure of 40 psi. The reaction mixture was filtered through Celite™ and concentrated in vacuo to afford the title compound as a white solid, 503 mg.

1. filtrationThe reaction mixture was filtered through Celite™
2. concentrationconcentrated in vacuo