反应详情

4-Chloro-1-ethyl-[1,2,4]triazolo-[4,3-a]quinoxaline (1.2 g., 0.005 mole), the product of Example 4, and 676 mg. (0.015 mole) of anhydrous dimethylamine in N,N-dimethylformamide (50 ml.) were stirred at 0° C. for 30 minutes and at room temperature for 2 hours. The reaction mixture was poured over ice and stirred for 20 minutes. The precipitate which formed was separated by filtration, washed with water and air dried. Recrystallization from chloroform and then from chloroform/cyclohexane afforded 510 mg. (42% yield) of 4-dimethylamino-1-ethyl-[1,2,4]triazolo[4,3-a]quinoxaline, m.p. 155°-158° C. Mass spectrum: m/e, 241 (P).

1. additionThe reaction mixture was poured over ice
2. customThe precipitate which formed
3. customwas separated by filtration
4. washwashed with water and air
5. customdried
6. customRecrystallization from chloroform
7. customfrom chloroform/cyclohexane afforded 510 mg