反应详情

Using the procedure of Step A of Example 15, 3.89 g of (S)α-cyano-3-phenoxy-benzyl(1R,cis)2,2-dimethyl-3-(2-carboxyethynyl)-cyclopropane-carboxylate and 1 g of neopentyl alcohol were reacted and the mixture was stirred at room temperature for 4 hours and was filtered. The filtrate was washed with N hydrochloric acid, with water, dried and evaporated to dryness under reduced pressure. The residue was chromatographed over silica gel and was eluted with an 8-2 cyclohexane-ethyl acetate mixture to obtain 3.8 g of (S)α-cyano-3-phenoxy-benzyl(1R,cis)2,2-dimethyl-3-[2-neopentyloxycarbonyl-ethynyl]-cyclopropane-carboxylate melting at 67° C.

1. customwere reacted
2. filtrationwas filtered
3. washThe filtrate was washed with N hydrochloric acid, with water
4. customdried
5. customevaporated to dryness under reduced pressure
6. customThe residue was chromatographed over silica gel
7. washwas eluted with an 8-2 cyclohexane-ethyl acetate mixture