HRID464836

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID13454680

未命名化合物

结构：Cl.N[C@H]1COc2ccccc2N(CC(=O)OCc2ccccc2)C1=O

HCID18599732

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)[C@@H](CCC1CCCCC1)N[C@H]1COc2ccccc2N(CC(=O)OCc2ccccc2)C1=O

HCID70046892

未命名化合物

收率 18.5%

PROCEDURE

实验过程

Benzyl 3(S)-amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetate hydrochloride (1.5 g) and ethyl 4-cyclohexyl-2-oxobutyrate (2.63 g) are subjected to reductive alkylation reaction in a manner similar to that described in Example 16, and the product is purified by silica gel column chromatography (hexane:ethal acetate=5:1-4:1). From the first fraction, 0.4 g of benzyl 3(S)-[1(R)-ethoxycarbonyl-3-cyclohexylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetate is obtained as a colorless oil.

WORKUP

后处理

customalkylation reaction in a manner similar to
customthe product is purified by silica gel column chromatography (hexane:ethal acetate=5:1-4:1)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e588394232fc485292af739d6142339c
来源数据集: uspto-grants-1985_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04548932
来源说明: uspto-grants-1985_10

反应 SMILES

Cl.[NH2:2][C@@H:3]1[C:9](=[O:10])[N:8]([CH2:11][C:12]([O:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[O:13])[C:7]2[CH:22]=[CH:23][CH:24]=[CH:25][C:6]=2[O:5][CH2:4]1.[CH:26]1([CH2:32][CH2:33][C:34](=O)[C:35]([O:37][CH2:38][CH3:39])=[O:36])[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1>>[CH2:38]([O:37][C:35]([C@H:34]([NH:2][C@@H:3]1[C:9](=[O:10])[N:8]([CH2:11][C:12]([O:14][CH2:15][C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)=[O:13])[C:7]2[CH:22]=[CH:23][CH:24]=[CH:25][C:6]=2[O:5][CH2:4]1)[CH2:33][CH2:32][CH:26]1[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31]1)=[O:36])[CH3:39]