反应详情

80 ml of 1 M diborane in tetrahydrofuran are added to the suspension of 6.8 g of [9-methoxy-2-oxo-3,4,5,5a,6,7-hexahydro-2H-naphth-[1,2-d]azepin-1-yl]-N-isopropyl-acetamide in 100 ml of tetrahydrofuran while stirring under nitrogen at 0°. After 20 hours 60 ml of 3 N hydrochloric acid are added dropwise and the mixture is refluxed for one hour. The tetrahydrofuran is distilled off under reduced pressure and the remainder is diluted with water. The resulting precipitate is filtered off and re-extracted with hot water. The aqueous filtrate is washed with diethyl ether and basified with 3 N aqueous sodium hydroxide. The suspension is extracted with methylene chloride, the extract dried, evaporated and the residue recrystallized from acetone, to yield the 1-(2-isopropylaminoethyl)-3,4,5,5a,6,7-hexahydro-9-methoxy-2H-naphth[1,2-d]azepin-2-one melting at 147°-149°.

1. temperaturethe mixture is refluxed for one hour
2. distillationThe tetrahydrofuran is distilled off under reduced pressure
3. additionthe remainder is diluted with water
4. filtrationThe resulting precipitate is filtered off
5. extractionre-extracted with hot water
6. washThe aqueous filtrate is washed with diethyl ether
7. extractionThe suspension is extracted with methylene chloride
8. customthe extract dried
9. customevaporated
10. customthe residue recrystallized from acetone