反应详情

NMR(CDCl3)δ: 0.88(6H,t), 1.58(4H,q), 2.09(3H,s), 3.24(2H,s), 4.13(2H,s), 5.10(2H,bs). d) To a solution of 3-acetoxy-2,2-diethyl-1-propanesulfonamide (6.5 g) in methanol (60 ml) was added 28 W/W % sodium methoxide methanol solution (5.2 g) at room temperature with stirring. After stirring for 40 minutes, the reaction mixture was concentrated to dryness, and the residue was subjected to a silica gel column chromatography, eluting with n-hexane-ethyl acetate (1:3). The corresponding fractions were concentrated to obtain 3-hydroxy-2,2-diethyl-1-propanesulfonamide (3.3 g).

1. stirringAfter stirring for 40 minutes
2. concentrationthe reaction mixture was concentrated to dryness
3. washeluting with n-hexane-ethyl acetate (1:3)
4. concentrationThe corresponding fractions were concentrated