3-Acetoxy-2,2-diethyl-1-propanesulfonamide → 3-Hydroxy-2,2-diethyl-1-propanesulfonamide

HRID 465937Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 465937
C([O:4][CH2:5][C:6]([CH2:14][CH3:15])([CH2:12][CH3:13])[CH2:7][S:8]([NH2:11])(=[O:10])=[O:9])(=O)C.CO.C[O-].[Na+]>CO>[OH:4][CH2:5][C:6]([CH2:14][CH3:15])([CH2:12][CH3:13])[CH2:7][S:8]([NH2:11])(=[O:9])=[O:10]

Komponenten

4

Edukt 2

HCID 106099273-Acetoxy-2,2-diethyl-1-propanesulfonamideHCID 23694274Sodium methanolate methanol

Produkt 1

HCID 105597653-Hydroxy-2,2-diethyl-1-propanesulfonamideAusbeute 61,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

NMR(CDCl3)δ: 0.88(6H,t), 1.58(4H,q), 2.09(3H,s), 3.24(2H,s), 4.13(2H,s), 5.10(2H,bs). d) To a solution of 3-acetoxy-2,2-diethyl-1-propanesulfonamide (6.5 g) in methanol (60 ml) was added 28 W/W % sodium methoxide methanol solution (5.2 g) at room temperature with stirring. After stirring for 40 minutes, the reaction mixture was concentrated to dryness, and the residue was subjected to a silica gel column chromatography, eluting with n-hexane-ethyl acetate (1:3). The corresponding fractions were concentrated to obtain 3-hydroxy-2,2-diethyl-1-propanesulfonamide (3.3 g).

Aufarbeitung

  1. stirringAfter stirring for 40 minutes
  2. concentrationthe reaction mixture was concentrated to dryness
  3. washeluting with n-hexane-ethyl acetate (1:3)
  4. concentrationThe corresponding fractions were concentrated

Quellen und Nachweise

ORD-Eintrag
ord-101abdaf6d3443a6a4ec82be3ea54a1f
Quelldatensatz
uspto-grants-1992_10
Patentnummer
US05155108

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