HCID 58127025, compound → HCID 67160458, compound

HRID 469574Notes

Reaction equation

HRID 469574 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([C:12]([F:15])([F:14])[F:13])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:16].[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([CH2:24][C:25](Cl)=[O:26])=[CH:20][C:19]=1[F:28]>>[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([CH2:24][C:25]([NH:1][N:2]2[N:11]=[C:10]([C:12]([F:15])([F:13])[F:14])[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]2=[O:16])=[O:26])=[CH:20][C:19]=1[F:28]

Participants

3

Reactant 2

HCID 58127025HCID 58127025, compoundHCID 671611112-amino-4-(trifluoromethyl)phthalazin-1(2H)-one

Product 1

HCID 67160458HCID 67160458, compound

Procedure

The product of Example 11B and 2-(4-chloro-3-fluorophenyl)acetyl chloride were treated using a method similar to that described in Example 1C to give the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 11.92-11.95 (bs, 1H), 8.43 (d, J=8.3 Hz, 1H), 8.11-8.17 (m, 1H), 7.99-8.08 (m, 2H), 7.58 (t, J=8.1 Hz, 1H), 7.43 (dd, J=10.5, 1.9 Hz, 1H), 7.25 (dd, J=8.3, 1.9 Hz, 1H), 3.79 (s, 2H); MS (ESI) m/z 400 (M+H)+.

Sources & evidence

ORD record
ord-c89122c321f7485498dbf6096cebc6d3
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

Loading…