2-(4-Methylcyclohexyl)acetic acid → HCID 67161256, compound

HRID 469643Notes

Reaction equation

HRID 469643 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:20].[CH3:21][CH:22]1[CH2:27][CH2:26][CH:25]([CH2:28][C:29](O)=[O:30])[CH2:24][CH2:23]1>>[CH3:19][O:18][C:15]1[CH:16]=[CH:17][C:12]([C:10]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3](=[O:20])[N:2]([NH:1][C:29](=[O:30])[CH2:28][CH:25]3[CH2:26][CH2:27][CH:22]([CH3:21])[CH2:23][CH2:24]3)[N:11]=2)=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 36169452-(4-Methylcyclohexyl)acetic acidHCID 67160105HCID 67160105, compound

Product 1

HCID 67161256HCID 67161256, compound

Procedure

The product from Example 151A and 2-(4-methylcyclohexyl)acetic acid were treated using a method similar to that described in Example 5 to give the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 11.31 (s, 1H), 8.37-8.44 (m, 1H), 7.86-8.04 (m, 2H), 7.74-7.80 (m, 1H), 7.51-7.55 (m, 2H), 7.10-7.14 (m, 2H), 3.85 (s, 3H), 2.23-2.34 (m, 2H), 1.95-2.09 (m, 1H), 1.77-1.88 (m, 1H), 1.42-1.72 (m, 5H), 1.20-1.35 (m, 2H), 0.88-1.06 (m, 1H), 0.92 (d, J=6.7 Hz, 3H); MS (ESI+) M/Z 406 (M+H)+.

Sources & evidence

ORD record
ord-7e5de6ee26f5437e8a115aec65e26727
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

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