Sodium Hydroxide → 2-Tert-butoxy-2-(4-(4-fluorophenyl)-2-isopropyl-8,8-dimethyl-5,6,7,8-tetrahydro-1,6-naphthyridin-3-yl)acetic acid

HRID 470930Notes

Reaction equation

HRID 470930 reaction equation
[C:1]([O:5][CH:6]([C:11]1[C:12]([CH:36]([CH3:38])[CH3:37])=[N:13][C:14]2[C:15]([CH3:35])([CH3:34])[CH2:16][N:17](C(=O)C(F)(F)F)[CH2:18][C:19]=2[C:20]=1[C:21]1[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=1)[C:7]([O:9]C)=[O:8])([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+].CC#N.O>CO>[C:1]([O:5][CH:6]([C:11]1[C:12]([CH:36]([CH3:38])[CH3:37])=[N:13][C:14]2[C:15]([CH3:35])([CH3:34])[CH2:16][NH:17][CH2:18][C:19]=2[C:20]=1[C:21]1[CH:22]=[CH:23][C:24]([F:27])=[CH:25][CH:26]=1)[C:7]([OH:9])=[O:8])([CH3:4])([CH3:3])[CH3:2]

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 18373917Acetonitrile--water (1/1)HCID 86692193Methyl 2-tert-butoxy-2-(4-(4-fluorophenyl)-2-isopropyl-8,8-dimethyl-6-(2,2,2-trifluoroacetyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-3-yl)acetate2×

Product 1

HCID 717115302-Tert-butoxy-2-(4-(4-fluorophenyl)-2-isopropyl-8,8-dimethyl-5,6,7,8-tetrahydro-1,6-naphthyridin-3-yl)acetic acidYield 32.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of methyl 2-tert-butoxy-2-(4-(4-fluorophenyl)-2-isopropyl-8,8-dimethyl-6-(2,2,2-trifluoroacetyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-3-yl)acetate (intermediate 4) (0.483 g, 0.897 mmol) and 1N NaOH (4.48 ml) in MeOH (10 mL) was stirred at room temperature overnight (15 h) and then 8 h at reflux. After cooling the product was purified by preparative-HPLC (CH3CN/H2O, 10 mmol NH4OAc) to provide 2-tert-butoxy-2-(4-(4-fluorophenyl)-2-isopropyl-8,8-dimethyl-5,6,7,8-tetrahydro-1,6-naphthyridin-3-yl)acetic acid (0.126 g, 31% yield). 1H NMR (500 MHz, DMSO-d6) δ ppm 7.37 (2H, d, J=6.7 Hz), 7.31 (2H, d, J=6.7 Hz), 4.67 (1H, s), 3.59 (1H, d, J=16.2 Hz), 3.51-3.57 (1H, m), 3.33 (2H, br. s.), 3.10 (1H, d, J=16.2 Hz), 2.72-2.82 (2H, m), 1.28 (6H, s), 1.19 (3H, d, J=6.4 Hz), 1.07 (3H, d, J=6.7 Hz), 0.87 (9H, s). LCMS (M+H) calcd for C25H34FN2O3: 429.26. found: 429.3.

Workup

  1. temperature8 h at reflux
  2. temperatureAfter cooling the product

Sources & evidence

ORD record
ord-0a80e27a8e334012a128d1d8317e31dd
Source dataset
uspto-grants-2014_01
Patent number
US08629276B2

Reaction notes

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