反应详情

A solution of (9-((5-(2-(tert-butyldimethylsilyloxy)ethyl)thiophen-2-yl)methyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-methylthiazol-4-yl)methanone (example 14, step b) (0.3 g) in THF (5 mL) was treated dropwise with a solution of tetrabutylammonium fluoride (1M in THF, 0.672 mL). The mixture was allowed to stand at 20° C. for 30 minutes. The solvents were evaporated using a stream of nitrogen and the residue was purified by flash silica chromatography, elution gradient 1% triethylamine and 2.5% methanol in dichloromethane. Pure fractions were evaporated to dryness to afford the subtitled compound. Yield 0.187 g.

1. customThe solvents were evaporated
2. customthe residue was purified by flash silica chromatography, elution gradient 1% triethylamine and 2.5% methanol in dichloromethane
3. customPure fractions were evaporated to dryness