反应详情

[8-(3-Methanesulfonyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-[4-(4-methyl-piperazin-1-yl)-phenyl]-amine was prepared from 8-(3-methanesulfonyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine (75.0 mg, 0.260 mmol) and 1-(4-bromo-phenyl)-4-methyl-piperazine (80.0 mg, 0.314 mmol) with 2,2′-bis-dicyclohexylphosphanyl-biphenyl (30.0 mg, 0.0549 mmol) as the ligand in a manner analogous to Step 2d and was isolated as a yellow foam (0.068 g, 56%). 1H NMR (400 MHz, CDCl3, δ, ppm): 8.66 (s, 1H), 8.45 (d, J=6.5 Hz, 1H), 8.38 (d, J=7.7 Hz, 1H), 7.99 (d, J=7.7 Hz, 1H), 7.73 (d, J=6.9 Hz, 1H), 7.66 (d, J=7.4 Hz, 1H), 7.50 (d, J=7.7 Hz, 1H), 7.00-6395 (m, 3H), 6.70 (s, 1H), 3.19-0.314 (m, 4H), 3.12 (s, 3H), 2.62-2.57 (m, 4H), 2.36 (s, 3H). MS=463 (MH)+.