反应详情

温度

0 °C

To (S)-methyl 3-((2-(1-methylethylsulfonamido)-2,3-dihydro-1H-inden-5-yl)methyl)-5-(trifluoromethyl)benzoate (0.044 mmol, 20 mg) at 0° C. in THF (1 mL) under an argon atmosphere was added Lithium aluminium hydride in THF (0.044 mmol, 0.044 mL) dropwise. The reaction was left to stir for 1.5 hrs at 0° C. The reaction was quenched with water before the addition of 5N HCl (aq) to adjust the pH to 5. The mixture was filtered through a celite cartridge before washing with EtOAc. The EtOAc layer was washed with water (×1) before drying the EtOAc over MgSO4. The solvent was removed in vacuo before purifying the crude (1:1 EtOAc/Heptane, 4 g silica cartridge) to give the title compound (7.5 mg, 40%). MS (ESI): m/z [M+Na]+ 450.0

1. waitThe reaction was left
2. customThe reaction was quenched with water before the addition of 5N HCl (aq)
3. filtrationThe mixture was filtered through a celite cartridge
4. washbefore washing with EtOAc
5. washThe EtOAc layer was washed with water (×1)
6. dry with materialbefore drying the EtOAc over MgSO4
7. customThe solvent was removed in vacuo
8. custombefore purifying the crude (1:1 EtOAc/Heptane, 4 g silica cartridge)