反应详情

13.5 g of tert-butyl 4-methylene-1-piperidinecarboxylate was dissolved in 300 ml methanol, and 28.3 g phthalic acid monoperacid magnesium salt and 8.62 g sodium bicarbonate were added thereto, and the mixture was stirred at room temperature for 1 day. The reaction solution was filtered through Celite, and the resulting filtrate was evaporated. Ethyl acetate was added to the resulting residue which was then washed with water and brine, dried over anhydrous magnesium sulfate, and then filtered. The filtrate was evaporated, and subjected to silica gel column chromatography to give 12.2 g of tert-butyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate.

1. filtrationThe reaction solution was filtered through Celite
2. customthe resulting filtrate was evaporated
3. additionEthyl acetate was added to the resulting residue which
4. washwas then washed with water and brine
5. dry with materialdried over anhydrous magnesium sulfate
6. filtrationfiltered
7. customThe filtrate was evaporated