反应详情

A solution of 1-(4-(2-(4-aminophenoxy)pyridin-3-yl)-5,6-dihydropyridin-1(2H)-yl)ethanone (0.98 g, 3.17 mmol) in ethanol (16 mL) was added palladium, 10 wt. % on carbon (0.1 g, 0.094 mmol) and hydrogenated (double-walled balloon pressure) at room temperature for 18 h. The reaction mixture was filtered via a pad of Celite, and the filtrate was concentrated in vacuo and chromatographed via flash column chromatography (20% to 80% EtOAc/Hexanes) to give 1-(4-(2-(4-aminophenoxy)pyridin-3-yl)piperidin-1-yl)ethanone as a light tan solid. MS (ESI, pos. ion) m/z: 312.0 (M+1).

1. filtrationThe reaction mixture was filtered via a pad of Celite
2. concentrationthe filtrate was concentrated in vacuo
3. customchromatographed via flash column chromatography (20% to 80% EtOAc/Hexanes)