反应详情

To a solution of 15 g (0.05 mole) 2-methoxy-4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]benzaldehyde in 50 ml of pyridine are added 11 g (0.11 mole) of malonic acid and 1 g of piperidine. The solution is stirred and gradually heated to 80°. Heating and stirring are continued for 1 hour at 80°. The solution is then heated at reflux for an additional 3 hours, cooled, and evaporated at reduced pressure to obtain a residual oil which is extracted into ether. The resulting ether solution is washed with water and 1N hydrochloric acid, dried with anhydrous magnesium sulfate, filtered, and evaporated at reduced pressure to obtain a residual solid which is recrystallized from chlorobutane/hexane mixed solvent to give 10.5 g of 3-{2 -methoxy-4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}-2-propenoic acid having a melting point of 138°-140°.

1. temperaturegradually heated to 80°
2. temperatureHeating
3. stirringstirring
4. temperatureThe solution is then heated
5. temperatureat reflux for an additional 3 hours
6. temperaturecooled
7. customevaporated at reduced pressure
8. customto obtain a residual oil which
9. extractionis extracted into ether
10. washThe resulting ether solution is washed with water and 1N hydrochloric acid
11. dry with materialdried with anhydrous magnesium sulfate
12. filtrationfiltered
13. customevaporated at reduced pressure
14. customto obtain a residual solid which
15. customis recrystallized from chlorobutane/hexane mixed solvent