反应详情

温度

175 °C

1,4,5,6-Tetrahydro-cyclopentapyrazole-3-carbonitrile (0.022 g, 0.165 mmol) and sodium azide (0.086 g, 1.30 mmol) were taken up in DMF (3 cm3) at heated under microwave irradiation to 175° C. for 20 minutes. The solution was cooled to room temperature, filtered and the filtered solid washed with ethyl acetate. The combined solutions was added to saturated aqueous sodium bicarbonate (20 cm3) and washed with ethyl acetate. The aqueous layer was acidified to pH 1 with the addition of 1M aqueous hydrochloric acid and extracted into ethyl acetate. The ethyl acetate washes were combined and solvent removed under reduced pressure, the resulting solid purified by preparative HPLC to give 3-(2H-tetrazol-5-yl)-1,4,5,6-tetrahydro-cyclopentapyrazole as a white solid (0.012 g, 0.068 mmol, 41%). 1H NMR δ (CD3OD): 2.88 (t-like, 2H, J=7.0), 2.82 (t-like, 2H, J=7.3), 2.64 (quintet-like, 2H, J=7.1); m/z (ES+): 177 [M+H]+.

1. temperatureThe solution was cooled to room temperature
2. filtrationfiltered
3. washthe filtered solid washed with ethyl acetate
4. additionThe combined solutions was added to saturated aqueous sodium bicarbonate (20 cm3)
5. washwashed with ethyl acetate
6. additionThe aqueous layer was acidified to pH 1 with the addition of 1M aqueous hydrochloric acid
7. extractionextracted into ethyl acetate
8. customsolvent removed under reduced pressure
9. customthe resulting solid purified by preparative HPLC